The Integrative Cardiac Biomechanics Laboratory is led by Dr. Stuart Campbell and located within the department of Biomedical Engineering at Yale University. We conduct translational research at the intersection of several disciplines, including cardiac muscle physiology, biomechanics, biophysics, tissue engineering, stem cell biology, and clinical cardiology. We have a passion for creating novel computational models, laboratory devices, and experimental methods to solve unmet clinical needs and address challenging questions in the realm of basic cardiac physiology.  Current areas of research interest include:

 

Inherited Cardiomyopathies – Discovering detailed disease mechanisms, predicting genotype-phenotype relationships, and improving clinical diagnostics/therapeutics.

 

Cardiomyocyte Function and Heterogeneity – Characterizing cell-to-cell variation in the myocardium and studying the cellular signaling pathways that regulate muscle contraction.

 

Cardiac tissue mechanobiology – Dissecting the role of biomechanical loads and extracellular matrix on cardiac remodeling and mechanotransduction.

 

You can learn more about each of these research areas, find recent lab publications, and meet current lab members in the following pages.